rs5219
KCNJ11rs5219 is a single-nucleotide polymorphism (SNP) in the KCNJ11 gene. Genespiral reads it in the Health & Wellness analysis to describe Type 2 Diabetes Risk.
- Gene
- KCNJ11
- Alleles
- C / T
- Genotypes
- TT, CT, CC
- Traits
- 1 trait across 1 analysis
An rsID such as rs5219 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of TT, CT, CC. The order of the two letters carries no meaning, so CT and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Type 2 Diabetes Risk
Metabolic Disorders · Part of the Health & Wellness analysis
Encodes a potassium channel protein that plays a role in insulin regulation.
| Genotype | Association |
|---|---|
| TT | Higher Risk |
| CT | Moderate Risk |
| CC | Lower Risk |
- Summary
- KCNJ11 gene variations affect insulin response, influencing risk of type 2 diabetes.
- Scientific insights
- 'TT' genotype individuals are at an increased risk of developing type 2 diabetes.
- Lifestyle tips
- Regular physical activity and a balanced diet can help mitigate diabetes risk.
Check your genotype at rs5219
Load your raw DNA file and Genespiral looks up rs5219 along with every other marker in the Health & Wellness analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Type 2 Diabetes Risk in your results.
Related
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs5219 - NCBI
- rs5219 variant page - Ensembl
- rs5219 summary - SNPedia
- Clinical significance records for rs5219 - ClinVar
- KCNJ11 gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.