rs334
HBBrs334 is a single-nucleotide polymorphism (SNP) in the HBB gene. Genespiral reads it in the Health & Wellness analysis to describe Malaria Resistance.
- Gene
- HBB
- Alleles
- A / T
- Genotypes
- TT, AT, AA
- Traits
- 1 trait across 1 analysis
An rsID such as rs334 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of TT, AT, AA. The order of the two letters carries no meaning, so AT and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Malaria Resistance
Infectious Disease Resistance · Part of the Health & Wellness analysis
A variant in the beta-globin gene (HbS). A single copy confers resistance to malaria; two copies cause sickle cell anemia.
| Genotype | Association |
|---|---|
| TT | Typical Hemoglobin (No Sickle Variant) |
| AT | Sickle Cell Trait (Carrier) — Malaria Resistance |
| AA | Two Sickle Variants (Sickle Cell Anemia) |
- Summary
- HBB variations: one copy provides malaria resistance (sickle cell trait), while two copies lead to sickle cell disease.
- Scientific insights
- The heterozygous 'AT' genotype (sickle cell trait) is protective against malaria, whereas 'AA' indicates two sickle variants (sickle cell anemia). 'TT' carries no sickle variant.
- Lifestyle tips
- This is a serious health-related variant. Consumer DNA results should be confirmed with clinical testing, and carriers may wish to seek genetic counseling when family planning.
Check your genotype at rs334
Load your raw DNA file and Genespiral looks up rs334 along with every other marker in the Health & Wellness analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Malaria Resistance in your results.
Related
More markers from Health & Wellness
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs334 - NCBI
- rs334 variant page - Ensembl
- rs334 summary - SNPedia
- Clinical significance records for rs334 - ClinVar
- HBB gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.