rs2200733
PITX2 (4q25)rs2200733 is a single-nucleotide polymorphism (SNP) in the PITX2 (4q25) gene. Genespiral reads it in the Health & Wellness analysis to describe Atrial Fibrillation Risk.
- Gene
- PITX2 (4q25)
- Alleles
- C / T
- Genotypes
- CC, CT, TT
- Traits
- 1 trait across 1 analysis
An rsID such as rs2200733 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of CC, CT, TT. The order of the two letters carries no meaning, so CT and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Atrial Fibrillation Risk
Cardiovascular Health · Part of the Health & Wellness analysis
A well-replicated variant in the chromosome 4q25 region near PITX2 associated with atrial fibrillation, the most common heart rhythm disorder.
| Genotype | Association |
|---|---|
| CC | Lower genetic risk |
| CT | Intermediate genetic risk |
| TT | Higher genetic risk |
- Summary
- The 4q25 locus is one of the strongest common genetic risk factors for atrial fibrillation.
- Scientific insights
- Each copy of the 'T' allele raises baseline genetic risk of atrial fibrillation, so 'TT' carries the highest; most carriers never develop it.
- Lifestyle tips
- Blood pressure control, activity, moderating alcohol, and a healthy weight all lower atrial fibrillation risk.
Check your genotype at rs2200733
Load your raw DNA file and Genespiral looks up rs2200733 along with every other marker in the Health & Wellness analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Atrial Fibrillation Risk in your results.
Related
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs2200733 - NCBI
- rs2200733 variant page - Ensembl
- rs2200733 summary - SNPedia
- Clinical significance records for rs2200733 - ClinVar
- PITX2 (4q25) gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.