rs1051730
CHRNA3rs1051730 is a single-nucleotide polymorphism (SNP) in the CHRNA3 gene. Genespiral reads it in the Health & Wellness analysis to describe Smoking Heaviness & Lung Risk.
- Gene
- CHRNA3
- Alleles
- A / G
- Genotypes
- GG, AG, AA
- Traits
- 1 trait across 1 analysis
An rsID such as rs1051730 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of GG, AG, AA. The order of the two letters carries no meaning, so AG and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Smoking Heaviness & Lung Risk
Addiction and Substance Response · Part of the Health & Wellness analysis
A nicotinic-receptor cluster variant linked to how heavily smokers smoke and, through that, to lung cancer and COPD risk; it does not determine whether someone smokes.
| Genotype | Association |
|---|---|
| GG | Lower tendency |
| AG | Intermediate tendency |
| AA | Higher tendency (more cigarettes if smoking) |
- Summary
- Among people who smoke, CHRNA3 genotype is associated with the number of cigarettes per day and related lung risk.
- Scientific insights
- Among smokers, each 'A' allele is associated with heavier smoking and higher lung-disease risk; the variant has little relevance for non-smokers.
- Lifestyle tips
- Not smoking removes the associated risk entirely; support is available for quitting.
Check your genotype at rs1051730
Load your raw DNA file and Genespiral looks up rs1051730 along with every other marker in the Health & Wellness analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Smoking Heaviness & Lung Risk in your results.
Related
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs1051730 - NCBI
- rs1051730 variant page - Ensembl
- rs1051730 summary - SNPedia
- Clinical significance records for rs1051730 - ClinVar
- CHRNA3 gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.