rs25531
SLC6A4rs25531 is a single-nucleotide polymorphism (SNP) in the SLC6A4 gene. Genespiral reads it in the Personality analysis to describe Emotional Reactivity.
- Gene
- SLC6A4
- Alleles
- C / T
- Genotypes
- TT, CT, CC
- Traits
- 1 trait across 1 analysis
An rsID such as rs25531 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of TT, CT, CC. The order of the two letters carries no meaning, so CT and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Emotional Reactivity
Emotional Traits · Part of the Personality analysis
A serotonin transporter (SLC6A4) promoter variant that modulates expression levels and emotional response.
| Genotype | Association |
|---|---|
| TT | Lower emotional reactivity |
| CT | Moderate emotional reactivity |
| CC | Higher emotional reactivity |
- Summary
- The rs25531 variant affects serotonin transporter expression, influencing how strongly individuals react to emotional stimuli.
- Scientific insights
- The lower-expressing 'CC' genotype is associated with heightened emotional responses to stress, while 'TT' is associated with lower reactivity.
- Lifestyle tips
- Practicing stress management can help manage high emotional reactivity.
Check your genotype at rs25531
Load your raw DNA file and Genespiral looks up rs25531 along with every other marker in the Personality analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Emotional Reactivity in your results.
Related
Other markers in SLC6A4
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs25531 - NCBI
- rs25531 variant page - Ensembl
- rs25531 summary - SNPedia
- Clinical significance records for rs25531 - ClinVar
- SLC6A4 gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.