rs644148
CHRNA4rs644148 is a single-nucleotide polymorphism (SNP) in the CHRNA4 gene. Genespiral reads it in the Personality analysis to describe Openness to Experience.
- Gene
- CHRNA4
- Alleles
- A / G
- Genotypes
- AA, AG, GG
- Traits
- 1 trait across 1 analysis
An rsID such as rs644148 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of AA, AG, GG. The order of the two letters carries no meaning, so AG and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Openness to Experience
Personality Traits · Part of the Personality analysis
Involved in neural signaling that may affect creativity, curiosity, and openness.
| Genotype | Association |
|---|---|
| AA | Higher openness |
| AG | Moderate openness |
| GG | Lower openness |
- Summary
- CHRNA4 variants can influence cognitive flexibility, a component of openness.
- Scientific insights
- Individuals with 'AA' often enjoy new ideas and exploring unfamiliar perspectives.
- Lifestyle tips
- Engaging in diverse cultural experiences can further enhance openness.
Check your genotype at rs644148
Load your raw DNA file and Genespiral looks up rs644148 along with every other marker in the Personality analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Openness to Experience in your results.
Related
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs644148 - NCBI
- rs644148 variant page - Ensembl
- rs644148 summary - SNPedia
- Clinical significance records for rs644148 - ClinVar
- CHRNA4 gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.