rs1799853
CYP2C9rs1799853 is a single-nucleotide polymorphism (SNP) in the CYP2C9 gene. Genespiral reads it in the Health & Wellness analysis to describe CYP2C9 Metabolism (Warfarin/NSAIDs).
- Gene
- CYP2C9
- Alleles
- C / T
- Genotypes
- CC, CT, TT
- Traits
- 1 trait across 1 analysis
An rsID such as rs1799853 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of CC, CT, TT. The order of the two letters carries no meaning, so CT and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
CYP2C9 Metabolism (Warfarin/NSAIDs)
Medication Response · Part of the Health & Wellness analysis
The CYP2C9*2 variant lowers activity of an enzyme that clears warfarin, some NSAIDs, and phenytoin; together with VKORC1 it guides warfarin dosing.
| Genotype | Association |
|---|---|
| CC | Normal CYP2C9 function |
| CT | Reduced metabolism (intermediate) |
| TT | Substantially reduced metabolism |
- Summary
- CYP2C9 genotype affects the metabolism of warfarin and several other drugs, influencing the dose needed.
- Scientific insights
- Carriers of the 'T' allele clear these drugs more slowly, so 'TT' individuals typically need lower doses of affected medications.
- Lifestyle tips
- Informational only — warfarin and other dosing must be managed clinically with appropriate monitoring.
Check your genotype at rs1799853
Load your raw DNA file and Genespiral looks up rs1799853 along with every other marker in the Health & Wellness analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find CYP2C9 Metabolism (Warfarin/NSAIDs) in your results.
Related
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs1799853 - NCBI
- rs1799853 variant page - Ensembl
- rs1799853 summary - SNPedia
- Clinical significance records for rs1799853 - ClinVar
- CYP2C9 gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.