rs1333049
CDKN2B-AS1 (9p21)rs1333049 is a single-nucleotide polymorphism (SNP) in the CDKN2B-AS1 (9p21) gene. Genespiral reads it in the Health & Wellness analysis to describe Coronary Artery Disease Risk.
- Gene
- CDKN2B-AS1 (9p21)
- Alleles
- C / G
- Genotypes
- CC, CG, GG
- Traits
- 1 trait across 1 analysis
An rsID such as rs1333049 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of CC, CG, GG. The order of the two letters carries no meaning, so CG and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Coronary Artery Disease Risk
Cardiovascular Health · Part of the Health & Wellness analysis
A well-replicated variant in the chromosome 9p21 region associated with coronary artery disease and heart attack risk.
| Genotype | Association |
|---|---|
| CC | Higher genetic risk |
| CG | Intermediate genetic risk |
| GG | Lower genetic risk |
- Summary
- The 9p21 locus is one of the most consistently replicated common genetic risk factors for coronary artery disease.
- Scientific insights
- Each copy of the 'C' allele modestly raises baseline genetic risk, so 'CC' individuals carry higher risk than 'GG'. This is one of many contributing factors.
- Lifestyle tips
- Genetic risk is not destiny — blood pressure, cholesterol, diet, exercise, and not smoking strongly influence cardiovascular outcomes.
Check your genotype at rs1333049
Load your raw DNA file and Genespiral looks up rs1333049 along with every other marker in the Health & Wellness analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Coronary Artery Disease Risk in your results.
Related
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs1333049 - NCBI
- rs1333049 variant page - Ensembl
- rs1333049 summary - SNPedia
- Clinical significance records for rs1333049 - ClinVar
- CDKN2B-AS1 (9p21) gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.