rs7216389
GSDMB/ORMDL3rs7216389 is a single-nucleotide polymorphism (SNP) in the GSDMB/ORMDL3 gene. Genespiral reads it in the Pet & Environmental Sensitivity analysis to describe Childhood-Onset Asthma Risk.
- Gene
- GSDMB/ORMDL3
- Alleles
- C / T
- Genotypes
- CC, CT, TT
- Traits
- 1 trait across 1 analysis
An rsID such as rs7216389 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of CC, CT, TT. The order of the two letters carries no meaning, so CT and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Childhood-Onset Asthma Risk
Respiratory Response · Part of the Pet & Environmental Sensitivity analysis
A variant in the chromosome 17q21 region (GSDMB/ORMDL3), the most strongly and consistently replicated common risk locus for childhood-onset asthma.
| Genotype | Association |
|---|---|
| CC | Lower genetic risk |
| CT | Intermediate genetic risk |
| TT | Higher genetic risk |
- Summary
- The 17q21 locus is the best-established common genetic risk factor for early-onset asthma.
- Scientific insights
- Each 'T' allele raises baseline genetic risk of childhood-onset asthma, so 'TT' is highest; early-life environment also matters greatly.
- Lifestyle tips
- Genetic risk is only part of the picture — discuss any breathing symptoms with a clinician.
Check your genotype at rs7216389
Load your raw DNA file and Genespiral looks up rs7216389 along with every other marker in the Pet & Environmental Sensitivity analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Childhood-Onset Asthma Risk in your results.
Related
More markers from Pet & Environmental Sensitivity
- rs20541 (IL13) - Allergic Sensitivity (Including Pet Allergies)
- rs2243250 (IL4) - Pollen Allergy Sensitivity
- rs2569190 (CD14) - Dust and Dust Mite Allergy Sensitivity
- rs9273349 (HLA-DQB1) - Mold Allergy Sensitivity
- rs11558538 (HNMT) - Insect Bite Reaction Severity
- rs61816761 (FLG) - Dust Mite Allergy Sensitivity
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs7216389 - NCBI
- rs7216389 variant page - Ensembl
- rs7216389 summary - SNPedia
- Clinical significance records for rs7216389 - ClinVar
- GSDMB/ORMDL3 gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.