rs11558538
HNMTrs11558538 is a single-nucleotide polymorphism (SNP) in the HNMT gene. Genespiral reads it in the Pet & Environmental Sensitivity analysis to describe Insect Bite Reaction Severity.
- Gene
- HNMT
- Alleles
- C / T
- Genotypes
- TT, CT, CC
- Traits
- 1 trait across 1 analysis
An rsID such as rs11558538 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of TT, CT, CC. The order of the two letters carries no meaning, so CT and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Insect Bite Reaction Severity
Insect Response · Part of the Pet & Environmental Sensitivity analysis
Histamine N-methyltransferase gene involved in histamine degradation.
| Genotype | Association |
|---|---|
| TT | Higher reaction severity |
| CT | Moderate reaction severity |
| CC | Lower reaction severity |
- Summary
- Variations in the HNMT gene can affect histamine metabolism, influencing the severity of reactions to insect bites.
- Scientific insights
- Individuals with the 'TT' genotype may have reduced histamine degradation, leading to more severe reactions.
- Lifestyle tips
- Using antihistamines can help manage symptoms after insect bites.
Check your genotype at rs11558538
Load your raw DNA file and Genespiral looks up rs11558538 along with every other marker in the Pet & Environmental Sensitivity analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Insect Bite Reaction Severity in your results.
Related
More markers from Pet & Environmental Sensitivity
- rs20541 (IL13) - Allergic Sensitivity (Including Pet Allergies)
- rs2243250 (IL4) - Pollen Allergy Sensitivity
- rs2569190 (CD14) - Dust and Dust Mite Allergy Sensitivity
- rs7216389 (GSDMB/ORMDL3) - Childhood-Onset Asthma Risk
- rs9273349 (HLA-DQB1) - Mold Allergy Sensitivity
- rs61816761 (FLG) - Dust Mite Allergy Sensitivity
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs11558538 - NCBI
- rs11558538 variant page - Ensembl
- rs11558538 summary - SNPedia
- Clinical significance records for rs11558538 - ClinVar
- HNMT gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.