rs4880
SOD2rs4880 is a single-nucleotide polymorphism (SNP) in the SOD2 gene. Genespiral reads it in the Aging & Longevity analysis to describe Oxidative Stress Response.
- Gene
- SOD2
- Alleles
- C / T
- Genotypes
- CC, CT, TT
- Traits
- 1 trait across 1 analysis
An rsID such as rs4880 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of CC, CT, TT. The order of the two letters carries no meaning, so CT and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Oxidative Stress Response
Cellular Aging · Part of the Aging & Longevity analysis
Key mitochondrial antioxidant enzyme.
| Genotype | Association |
|---|---|
| CC | Enhanced antioxidant activity |
| CT | Typical activity |
| TT | Modified activity |
- Summary
- Functional variant affecting enzyme activity.
- Scientific insights
- Effect most notable under oxidative stress conditions.
- Lifestyle tips
- Antioxidant-rich diet beneficial for all profiles.
Check your genotype at rs4880
Load your raw DNA file and Genespiral looks up rs4880 along with every other marker in the Aging & Longevity analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Oxidative Stress Response in your results.
Related
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs4880 - NCBI
- rs4880 variant page - Ensembl
- rs4880 summary - SNPedia
- Clinical significance records for rs4880 - ClinVar
- SOD2 gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.