rs1426654
SLC24A5rs1426654 is a single-nucleotide polymorphism (SNP) in the SLC24A5 gene. Genespiral reads it in the Appearance and Aging & Longevity analyses to describe Skin Tone and Skin Pigmentation.
- Gene
- SLC24A5
- Alleles
- A / G
- Genotypes
- AA, AG, GG
- Traits
- 2 traits across 2 analyses
An rsID such as rs1426654 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of AA, AG, GG. The order of the two letters carries no meaning, so AG and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Skin Tone
Appearance · Part of the Appearance analysis
Plays a significant role in determining skin pigmentation.
| Genotype | Association |
|---|---|
| AA | Lighter Skin Tone |
| AG | Medium Skin Tone |
| GA | Medium Skin Tone |
| GG | Darker Skin Tone |
- Summary
- Associated with variations in skin tone due to melanin levels.
- Scientific insights
- Individuals with 'AA' tend to have lighter skin, while 'GG' correlates with darker skin.
- Lifestyle tips
- Use appropriate sun protection regardless of skin tone.
Skin Pigmentation
Dermatological Aging · Part of the Aging & Longevity analysis
Influences melanin production and distribution.
| Genotype | Association |
|---|---|
| AA | Typical light pigmentation pattern |
| AG | Intermediate pigmentation pattern |
| GG | Typical darker pigmentation pattern |
- Summary
- One of several genes affecting baseline skin pigmentation.
- Scientific insights
- Environmental factors significantly affect age-related changes.
- Lifestyle tips
- Sun protection important regardless of base pigmentation.
Check your genotype at rs1426654
Load your raw DNA file and Genespiral looks up rs1426654 along with every other marker in the Appearance and Aging & Longevity analyses. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Skin Tone and Skin Pigmentation in your results.
Related
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs1426654 - NCBI
- rs1426654 variant page - Ensembl
- rs1426654 summary - SNPedia
- Clinical significance records for rs1426654 - ClinVar
- SLC24A5 gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.