rs7903146
TCF7L2rs7903146 is a single-nucleotide polymorphism (SNP) in the TCF7L2 gene. Genespiral reads it in the Aging & Longevity and Miscellaneous Traits analyses to describe Insulin Sensitivity and Type 2 Diabetes Risk.
- Gene
- TCF7L2
- Alleles
- C / T
- Genotypes
- CC, CT, TT
- Traits
- 2 traits across 2 analyses
An rsID such as rs7903146 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of CC, CT, TT. The order of the two letters carries no meaning, so CT and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Insulin Sensitivity
Metabolic Aging · Part of the Aging & Longevity analysis
Influences glucose metabolism.
| Genotype | Association |
|---|---|
| CC | Typical insulin sensitivity |
| CT | Slight variation in sensitivity |
| TT | Modified insulin response |
- Summary
- Well-studied diabetes risk variant.
- Scientific insights
- Diet and exercise strongly modify effect.
- Lifestyle tips
- Healthy diet and regular activity benefit all profiles.
Type 2 Diabetes Risk
Health Risk · Part of the Miscellaneous Traits analysis
Linked to insulin production and glucose metabolism.
| Genotype | Association |
|---|---|
| CC | Lower Risk |
| CT | Moderate Risk |
| TT | Higher Risk |
- Summary
- Associated with increased risk of type 2 diabetes.
- Scientific insights
- 'TT' carriers have a higher risk, while 'CC' is linked to lower risk of type 2 diabetes.
- Lifestyle tips
- Maintain a healthy weight and diet to reduce diabetes risk.
Check your genotype at rs7903146
Load your raw DNA file and Genespiral looks up rs7903146 along with every other marker in the Aging & Longevity and Miscellaneous Traits analyses. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Insulin Sensitivity and Type 2 Diabetes Risk in your results.
Related
More markers from Aging & Longevity and Miscellaneous Traits
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs7903146 - NCBI
- rs7903146 variant page - Ensembl
- rs7903146 summary - SNPedia
- Clinical significance records for rs7903146 - ClinVar
- TCF7L2 gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.