rs1801282
PPARGrs1801282 is a single-nucleotide polymorphism (SNP) in the PPARG gene. Genespiral reads it in the Health & Wellness analysis to describe Type 2 Diabetes Risk (PPARG).
- Gene
- PPARG
- Alleles
- C / G
- Genotypes
- CC, CG, GG
- Traits
- 1 trait across 1 analysis
An rsID such as rs1801282 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of CC, CG, GG. The order of the two letters carries no meaning, so CG and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Type 2 Diabetes Risk (PPARG)
Metabolic Disorders · Part of the Health & Wellness analysis
The PPARG Pro12Ala variant affects a key regulator of fat cells and insulin sensitivity; the Ala (G) allele is linked to modestly improved insulin sensitivity.
| Genotype | Association |
|---|---|
| CC | Baseline (Pro12) risk |
| CG | Slightly lower risk |
| GG | Lower risk (Ala12) |
- Summary
- PPARG genotype has a small, well-replicated effect on type 2 diabetes risk and insulin sensitivity.
- Scientific insights
- Each 'G' (Ala12) allele is associated with slightly lower type 2 diabetes risk, so 'GG' is the most protective; the effect is small.
- Lifestyle tips
- Weight management, activity, and diet have far larger effects on diabetes risk than this variant.
Check your genotype at rs1801282
Load your raw DNA file and Genespiral looks up rs1801282 along with every other marker in the Health & Wellness analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Type 2 Diabetes Risk (PPARG) in your results.
Related
Other markers in PPARG
- rs1799883 - Fat Metabolism
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs1801282 - NCBI
- rs1801282 variant page - Ensembl
- rs1801282 summary - SNPedia
- Clinical significance records for rs1801282 - ClinVar
- PPARG gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.