rs3135388
HLA-DRB1rs3135388 is a single-nucleotide polymorphism (SNP) in the HLA-DRB1 gene. Genespiral reads it in the Health & Wellness analysis to describe Multiple Sclerosis Risk.
- Gene
- HLA-DRB1
- Alleles
- A / G
- Genotypes
- AA, AG, GG
- Traits
- 1 trait across 1 analysis
An rsID such as rs3135388 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of AA, AG, GG. The order of the two letters carries no meaning, so AG and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Multiple Sclerosis Risk
Autoimmune and Inflammatory Conditions · Part of the Health & Wellness analysis
Associated with immune response regulation, impacting susceptibility to autoimmune conditions.
| Genotype | Association |
|---|---|
| AA | Increased Risk |
| AG | Moderate Risk |
| GG | Lower Risk |
- Summary
- HLA-DRB1 gene variations are linked to an increased risk of developing multiple sclerosis (MS).
- Scientific insights
- 'AA' genotype is associated with a higher likelihood of MS, especially in certain populations.
- Lifestyle tips
- Maintaining a healthy lifestyle and consulting with healthcare providers can help manage MS risk.
Check your genotype at rs3135388
Load your raw DNA file and Genespiral looks up rs3135388 along with every other marker in the Health & Wellness analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Multiple Sclerosis Risk in your results.
Related
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs3135388 - NCBI
- rs3135388 variant page - Ensembl
- rs3135388 summary - SNPedia
- Clinical significance records for rs3135388 - ClinVar
- HLA-DRB1 gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.