rs1800562
HFErs1800562 is a single-nucleotide polymorphism (SNP) in the HFE gene. Genespiral reads it in the Health & Wellness analysis to describe Hereditary Hemochromatosis Risk.
- Gene
- HFE
- Alleles
- A / G
- Genotypes
- GG, AG, AA
- Traits
- 1 trait across 1 analysis
An rsID such as rs1800562 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of GG, AG, AA. The order of the two letters carries no meaning, so AG and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Hereditary Hemochromatosis Risk
Metabolic and Nutritional · Part of the Health & Wellness analysis
The HFE C282Y variant affects iron absorption; two copies can lead to iron overload (hereditary hemochromatosis).
| Genotype | Association |
|---|---|
| GG | Typical iron regulation |
| AG | Carrier (one C282Y copy) |
| AA | Higher risk of iron overload |
- Summary
- HFE variations influence how much dietary iron the body absorbs and stores.
- Scientific insights
- The 'AA' genotype (two C282Y copies) carries the highest risk of iron overload, though penetrance is incomplete and many never develop symptoms. 'AG' carriers are usually unaffected.
- Lifestyle tips
- This is an informational result, not a diagnosis. Iron studies (ferritin, transferrin saturation) and a clinician can confirm iron status.
Check your genotype at rs1800562
Load your raw DNA file and Genespiral looks up rs1800562 along with every other marker in the Health & Wellness analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Hereditary Hemochromatosis Risk in your results.
Related
Other markers in HFE
- rs1799945 - Iron Metabolism and Endurance
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs1800562 - NCBI
- rs1800562 variant page - Ensembl
- rs1800562 summary - SNPedia
- Clinical significance records for rs1800562 - ClinVar
- HFE gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.