rs143383
GDF5rs143383 is a single-nucleotide polymorphism (SNP) in the GDF5 gene. Genespiral reads it in the Aging & Longevity analysis to describe Joint Health.
- Gene
- GDF5
- Alleles
- C / T
- Genotypes
- CC, CT, TT
- Traits
- 1 trait across 1 analysis
An rsID such as rs143383 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of CC, CT, TT. The order of the two letters carries no meaning, so CT and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Joint Health
Musculoskeletal Aging · Part of the Aging & Longevity analysis
Influences cartilage development and maintenance.
| Genotype | Association |
|---|---|
| CC | Typical joint characteristics |
| CT | Slight variation in characteristics |
| TT | Modified joint characteristics |
- Summary
- One of several genes affecting joint health.
- Scientific insights
- Weight and activity level strongly influence outcomes.
- Lifestyle tips
- Joint-friendly exercise benefits all genetic profiles.
Check your genotype at rs143383
Load your raw DNA file and Genespiral looks up rs143383 along with every other marker in the Aging & Longevity analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Joint Health in your results.
Related
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs143383 - NCBI
- rs143383 variant page - Ensembl
- rs143383 summary - SNPedia
- Clinical significance records for rs143383 - ClinVar
- GDF5 gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.