rs9923231
VKORC1rs9923231 is a single-nucleotide polymorphism (SNP) in the VKORC1 gene. Genespiral reads it in the Health & Wellness analysis to describe Warfarin Sensitivity.
- Gene
- VKORC1
- Alleles
- C / T
- Genotypes
- CC, CT, TT
- Traits
- 1 trait across 1 analysis
An rsID such as rs9923231 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of CC, CT, TT. The order of the two letters carries no meaning, so CT and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Warfarin Sensitivity
Medication Response · Part of the Health & Wellness analysis
A VKORC1 promoter variant (−1639G>A) that lowers the gene’s expression, increasing sensitivity to the blood thinner warfarin.
| Genotype | Association |
|---|---|
| CC | Standard warfarin sensitivity |
| CT | Intermediate sensitivity |
| TT | Higher sensitivity (lower dose typically needed) |
- Summary
- VKORC1 genotype is a major predictor of the warfarin dose needed and is used in clinical dosing algorithms.
- Scientific insights
- The 'TT' genotype is associated with higher warfarin sensitivity and typically lower dose requirements, while 'CC' is associated with standard requirements.
- Lifestyle tips
- Informational only — warfarin dosing must be managed by a clinician using INR monitoring, not genetics alone.
Check your genotype at rs9923231
Load your raw DNA file and Genespiral looks up rs9923231 along with every other marker in the Health & Wellness analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Warfarin Sensitivity in your results.
Related
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs9923231 - NCBI
- rs9923231 variant page - Ensembl
- rs9923231 summary - SNPedia
- Clinical significance records for rs9923231 - ClinVar
- VKORC1 gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.