rs9536314
KL (Klotho)rs9536314 is a single-nucleotide polymorphism (SNP) in the KL (Klotho) gene. Genespiral reads it in the Aging & Longevity analysis to describe Cognitive Aging (KLOTHO KL-VS).
- Gene
- KL (Klotho)
- Alleles
- G / T
- Genotypes
- TT, TG, GG
- Traits
- 1 trait across 1 analysis
An rsID such as rs9536314 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of TT, TG, GG. The order of the two letters carries no meaning, so TG and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Cognitive Aging (KLOTHO KL-VS)
Cognitive Aging · Part of the Aging & Longevity analysis
The KLOTHO "KL-VS" variant shows an unusual heterozygote advantage: carrying a single copy is associated with better cognitive aging and longevity, while two copies are not.
| Genotype | Association |
|---|---|
| TT | Typical (KL-VS non-carrier) |
| TG | Associated with better cognitive aging & longevity |
| GG | Reduced KL-VS benefit |
- Summary
- One copy of the KLOTHO KL-VS variant is associated with enhanced cognition and longer lifespan; two copies lose that benefit.
- Scientific insights
- Heterozygotes ('TG') are the group linked to better cognitive aging and longevity; non-carriers ('TT') are typical and homozygotes ('GG') do not share the advantage.
- Lifestyle tips
- This is a small, probabilistic research association, not a measure of your cognitive ability.
Check your genotype at rs9536314
Load your raw DNA file and Genespiral looks up rs9536314 along with every other marker in the Aging & Longevity analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Cognitive Aging (KLOTHO KL-VS) in your results.
Related
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs9536314 - NCBI
- rs9536314 variant page - Ensembl
- rs9536314 summary - SNPedia
- Clinical significance records for rs9536314 - ClinVar
- KL (Klotho) gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.