rs3736228
LRP5rs3736228 is a single-nucleotide polymorphism (SNP) in the LRP5 gene. Genespiral reads it in the Aging & Longevity analysis to describe Bone Mineral Density.
- Gene
- LRP5
- Alleles
- C / T
- Genotypes
- CC, CT, TT
- Traits
- 1 trait across 1 analysis
An rsID such as rs3736228 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of CC, CT, TT. The order of the two letters carries no meaning, so CT and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Bone Mineral Density
Skeletal Aging · Part of the Aging & Longevity analysis
Regulates bone formation through Wnt signaling.
| Genotype | Association |
|---|---|
| CC | Typical bone density |
| CT | Slightly decreased density |
| TT | Moderately decreased density |
- Summary
- Important but not sole determinant of bone density.
- Scientific insights
- Environmental factors often have greater impact than genetic variants.
- Lifestyle tips
- Regular exercise and adequate calcium/vitamin D intake are crucial.
Check your genotype at rs3736228
Load your raw DNA file and Genespiral looks up rs3736228 along with every other marker in the Aging & Longevity analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Bone Mineral Density in your results.
Related
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs3736228 - NCBI
- rs3736228 variant page - Ensembl
- rs3736228 summary - SNPedia
- Clinical significance records for rs3736228 - ClinVar
- LRP5 gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.