rs6983267
CASC8/CCAT2 (8q24)rs6983267 is a single-nucleotide polymorphism (SNP) in the CASC8/CCAT2 (8q24) gene. Genespiral reads it in the Health & Wellness analysis to describe Colorectal Cancer Risk.
- Gene
- CASC8/CCAT2 (8q24)
- Alleles
- G / T
- Genotypes
- GG, GT, TT
- Traits
- 1 trait across 1 analysis
An rsID such as rs6983267 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of GG, GT, TT. The order of the two letters carries no meaning, so GT and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Colorectal Cancer Risk
Cancer Risk · Part of the Health & Wellness analysis
A common variant in the chromosome 8q24 region associated with colorectal (and, separately, prostate) cancer risk via a regulatory element.
| Genotype | Association |
|---|---|
| GG | Higher genetic risk |
| GT | Intermediate genetic risk |
| TT | Lower genetic risk |
- Summary
- The 8q24 locus is a well-replicated common risk factor for colorectal cancer, with a modest per-allele effect.
- Scientific insights
- Each 'G' allele modestly raises baseline colorectal cancer risk, so 'GG' is highest; this is one small factor among many.
- Lifestyle tips
- Screening as advised, a fibre-rich diet, activity, and not smoking are the main levers for colorectal cancer risk.
Check your genotype at rs6983267
Load your raw DNA file and Genespiral looks up rs6983267 along with every other marker in the Health & Wellness analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Colorectal Cancer Risk in your results.
Related
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs6983267 - NCBI
- rs6983267 variant page - Ensembl
- rs6983267 summary - SNPedia
- Clinical significance records for rs6983267 - ClinVar
- CASC8/CCAT2 (8q24) gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.