rs4988235
MCM6rs4988235 is a single-nucleotide polymorphism (SNP) in the MCM6 gene. Genespiral reads it in the Miscellaneous Traits analysis to describe Lactose Tolerance.
- Gene
- MCM6
- Alleles
- C / T
- Genotypes
- CC, CT, TT
- Traits
- 1 trait across 1 analysis
An rsID such as rs4988235 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of CC, CT, TT. The order of the two letters carries no meaning, so CT and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Lactose Tolerance
Dietary Preferences · Part of the Miscellaneous Traits analysis
Regulates lactase persistence, allowing for continued lactose digestion in adulthood.
| Genotype | Association |
|---|---|
| CC | Lactose Intolerant |
| CT | Lactose Tolerant |
| TT | Lactose Tolerant |
- Summary
- MCM6 gene variations affect lactose tolerance, common in populations with a history of dairy farming.
- Scientific insights
- 'TT' genotype is associated with lactase persistence, allowing for lactose tolerance into adulthood.
- Lifestyle tips
- Lactase supplements may help those with intolerance to digest dairy products.
Check your genotype at rs4988235
Load your raw DNA file and Genespiral looks up rs4988235 along with every other marker in the Miscellaneous Traits analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Lactose Tolerance in your results.
Related
Other markers in MCM6
- rs182549 - Lactose Tolerance
More markers from Miscellaneous Traits
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs4988235 - NCBI
- rs4988235 variant page - Ensembl
- rs4988235 summary - SNPedia
- Clinical significance records for rs4988235 - ClinVar
- MCM6 gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.