rs429358
APOErs429358 is a single-nucleotide polymorphism (SNP) in the APOE gene. Genespiral reads it in the Personality, Learning & Cognition and Miscellaneous Traits analyses to describe Emotional Resilience, Risk of Memory Decline with Age and Alzheimer's Disease Risk.
- Gene
- APOE
- Alleles
- C / T
- Genotypes
- CC, CT, TT
- Traits
- 3 traits across 3 analyses
An rsID such as rs429358 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of CC, CT, TT. The order of the two letters carries no meaning, so CT and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Emotional Resilience
Emotional Traits · Part of the Personality analysis
Involved in lipid metabolism, which can influence brain health and emotional resilience.
| Genotype | Association |
|---|---|
| CC | Higher emotional resilience |
| CT | Moderate resilience |
| TT | Lower resilience |
- Summary
- Variants in APOE may impact stress response and emotional resilience.
- Scientific insights
- Individuals with 'CC' are often more resilient in stressful situations.
- Lifestyle tips
- Building a strong social support network can enhance emotional resilience.
Risk of Memory Decline with Age
Memory · Part of the Learning & Cognition analysis
Apolipoprotein E gene associated with lipid metabolism and neuronal repair.
| Genotype | Association |
|---|---|
| CC | Higher risk of memory decline |
| CT | Moderate risk |
| TT | Lower risk of memory decline |
- Summary
- Variations in the APOE gene affect the risk of cognitive decline and Alzheimer’s disease.
- Scientific insights
- Individuals with the 'CC' genotype (associated with the APOE ε4 allele) have a higher risk of memory decline.
- Lifestyle tips
- Healthy lifestyle choices like regular exercise and a balanced diet can support brain health.
Alzheimer's Disease Risk
Health Risk · Part of the Miscellaneous Traits analysis
APOE gene variants are associated with the risk of developing Alzheimer’s disease.
| Genotype | Association |
|---|---|
| CC | Increased Risk |
| CT | Moderate Risk |
| TT | Lower Risk |
- Summary
- Genetic variations impact susceptibility to Alzheimer’s, especially in late adulthood.
- Scientific insights
- 'CC' carriers show a higher risk, while 'TT' alleles are linked to lower susceptibility.
- Lifestyle tips
- Consider lifestyle adjustments and regular cognitive activities as preventive measures.
Check your genotype at rs429358
Load your raw DNA file and Genespiral looks up rs429358 along with every other marker in the Personality, Learning & Cognition and Miscellaneous Traits analyses. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Emotional Resilience and Risk of Memory Decline with Age in your results.
Related
Other markers in APOE
- rs7412 - Attention to Detail and Risk of Alzheimer's Disease
More markers from Personality, Learning & Cognition and Miscellaneous Traits
Articles that discuss rs429358
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs429358 - NCBI
- rs429358 variant page - Ensembl
- rs429358 summary - SNPedia
- Clinical significance records for rs429358 - ClinVar
- APOE gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.