rs4244285
CYP2C19rs4244285 is a single-nucleotide polymorphism (SNP) in the CYP2C19 gene. Genespiral reads it in the Health & Wellness analysis to describe CYP2C19 Metabolism (Clopidogrel/PPIs).
- Gene
- CYP2C19
- Alleles
- A / G
- Genotypes
- GG, AG, AA
- Traits
- 1 trait across 1 analysis
An rsID such as rs4244285 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of GG, AG, AA. The order of the two letters carries no meaning, so AG and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
CYP2C19 Metabolism (Clopidogrel/PPIs)
Medication Response · Part of the Health & Wellness analysis
The CYP2C19*2 loss-of-function variant reduces an enzyme that activates clopidogrel and clears drugs such as proton-pump inhibitors and some antidepressants.
| Genotype | Association |
|---|---|
| GG | Normal CYP2C19 function |
| AG | Intermediate metabolizer |
| AA | Poor metabolizer |
- Summary
- CYP2C19 genotype affects how well certain medications — notably the antiplatelet clopidogrel — are metabolized.
- Scientific insights
- 'AA' (poor metabolizer) individuals activate clopidogrel poorly, which can reduce its effect; 'GG' is normal function.
- Lifestyle tips
- Informational only. Medication choices must be made with a clinician, who can order clinical pharmacogenomic testing if relevant.
Check your genotype at rs4244285
Load your raw DNA file and Genespiral looks up rs4244285 along with every other marker in the Health & Wellness analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find CYP2C19 Metabolism (Clopidogrel/PPIs) in your results.
Related
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs4244285 - NCBI
- rs4244285 variant page - Ensembl
- rs4244285 summary - SNPedia
- Clinical significance records for rs4244285 - ClinVar
- CYP2C19 gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.