rs4149056
SLCO1B1rs4149056 is a single-nucleotide polymorphism (SNP) in the SLCO1B1 gene. Genespiral reads it in the Health & Wellness analysis to describe Statin-Induced Muscle Effects.
- Gene
- SLCO1B1
- Alleles
- C / T
- Genotypes
- TT, CT, CC
- Traits
- 1 trait across 1 analysis
An rsID such as rs4149056 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of TT, CT, CC. The order of the two letters carries no meaning, so CT and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Statin-Induced Muscle Effects
Medication Response · Part of the Health & Wellness analysis
The SLCO1B1 *5 variant reduces a liver transporter that clears statins, raising blood levels and the chance of statin-related muscle symptoms.
| Genotype | Association |
|---|---|
| TT | Typical statin transport |
| CT | Intermediate — modestly higher risk |
| CC | Higher risk of statin-related muscle effects |
- Summary
- SLCO1B1 genotype influences statin blood levels and the likelihood of muscle side effects, especially with simvastatin.
- Scientific insights
- The 'CC' genotype carries the highest risk of statin-associated muscle effects; 'TT' is typical. Risk also depends on the specific statin and dose.
- Lifestyle tips
- Informational only — never change a prescribed medication based on this. Discuss statin choice and dosing with your clinician.
Check your genotype at rs4149056
Load your raw DNA file and Genespiral looks up rs4149056 along with every other marker in the Health & Wellness analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Statin-Induced Muscle Effects in your results.
Related
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs4149056 - NCBI
- rs4149056 variant page - Ensembl
- rs4149056 summary - SNPedia
- Clinical significance records for rs4149056 - ClinVar
- SLCO1B1 gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.