rs4112788
PLEKHS1rs4112788 is a single-nucleotide polymorphism (SNP) in the PLEKHS1 gene. Genespiral reads it in the Health & Wellness analysis to describe Acne Risk.
- Gene
- PLEKHS1
- Alleles
- C / T
- Genotypes
- CC, CT, TT
- Traits
- 1 trait across 1 analysis
An rsID such as rs4112788 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of CC, CT, TT. The order of the two letters carries no meaning, so CT and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Acne Risk
Skin and Hair Conditions · Part of the Health & Wellness analysis
Linked to inflammation and oil gland activity, influencing acne susceptibility.
| Genotype | Association |
|---|---|
| CC | Increased Risk |
| CT | Moderate Risk |
| TT | Lower Risk |
- Summary
- PLEKHS1 gene variations are associated with a higher or lower risk of acne.
- Scientific insights
- 'CC' genotype may indicate a higher likelihood of developing acne, particularly in adolescence.
- Lifestyle tips
- Regular skincare and a balanced diet may help manage acne risk.
Check your genotype at rs4112788
Load your raw DNA file and Genespiral looks up rs4112788 along with every other marker in the Health & Wellness analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Acne Risk in your results.
Related
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs4112788 - NCBI
- rs4112788 variant page - Ensembl
- rs4112788 summary - SNPedia
- Clinical significance records for rs4112788 - ClinVar
- PLEKHS1 gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.