rs2814778
ACKR1 (DARC)rs2814778 is a single-nucleotide polymorphism (SNP) in the ACKR1 (DARC) gene. Genespiral reads it in the Health & Wellness analysis to describe Malaria Resistance (Plasmodium vivax).
- Gene
- ACKR1 (DARC)
- Alleles
- C / T
- Genotypes
- TT, CT, CC
- Traits
- 1 trait across 1 analysis
An rsID such as rs2814778 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of TT, CT, CC. The order of the two letters carries no meaning, so CT and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Malaria Resistance (Plasmodium vivax)
Infectious Disease Resistance · Part of the Health & Wellness analysis
A promoter variant that silences the Duffy antigen on red blood cells, removing the receptor Plasmodium vivax uses to invade them.
| Genotype | Association |
|---|---|
| TT | Duffy-positive (susceptible to P. vivax) |
| CT | Intermediate |
| CC | Duffy-null (resistant to P. vivax) |
- Summary
- The Duffy-null genotype provides near-complete resistance to Plasmodium vivax malaria and is common in African populations.
- Scientific insights
- The 'CC' (Duffy-null) genotype resists P. vivax malaria and is also linked to a benign, naturally lower white blood cell count. It does not protect against Plasmodium falciparum malaria.
- Lifestyle tips
- This trait reflects red-cell biology; a benign lower neutrophil count in Duffy-null individuals is normal and not a sign of illness.
Check your genotype at rs2814778
Load your raw DNA file and Genespiral looks up rs2814778 along with every other marker in the Health & Wellness analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Malaria Resistance (Plasmodium vivax) in your results.
Related
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs2814778 - NCBI
- rs2814778 variant page - Ensembl
- rs2814778 summary - SNPedia
- Clinical significance records for rs2814778 - ClinVar
- ACKR1 (DARC) gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.