rs2476601
PTPN22rs2476601 is a single-nucleotide polymorphism (SNP) in the PTPN22 gene. Genespiral reads it in the Health & Wellness analysis to describe Rheumatoid Arthritis Risk.
- Gene
- PTPN22
- Alleles
- A / G
- Genotypes
- AA, AG, GG
- Traits
- 1 trait across 1 analysis
An rsID such as rs2476601 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of AA, AG, GG. The order of the two letters carries no meaning, so AG and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Rheumatoid Arthritis Risk
Autoimmune and Inflammatory Conditions · Part of the Health & Wellness analysis
Involved in immune system function, linked to inflammation and autoimmunity.
| Genotype | Association |
|---|---|
| AA | Increased Risk |
| AG | Moderate Risk |
| GG | Lower Risk |
- Summary
- PTPN22 gene variations are associated with susceptibility to rheumatoid arthritis.
- Scientific insights
- 'AA' genotype increases risk of rheumatoid arthritis, especially in those with a family history.
- Lifestyle tips
- Anti-inflammatory diets and physical activity can support joint health.
Check your genotype at rs2476601
Load your raw DNA file and Genespiral looks up rs2476601 along with every other marker in the Health & Wellness analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Rheumatoid Arthritis Risk in your results.
Related
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs2476601 - NCBI
- rs2476601 variant page - Ensembl
- rs2476601 summary - SNPedia
- Clinical significance records for rs2476601 - ClinVar
- PTPN22 gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.