rs16969968
CHRNA5rs16969968 is a single-nucleotide polymorphism (SNP) in the CHRNA5 gene. Genespiral reads it in the Health & Wellness analysis to describe Nicotine Dependence Risk.
- Gene
- CHRNA5
- Alleles
- A / G
- Genotypes
- AA, AG, GG
- Traits
- 1 trait across 1 analysis
An rsID such as rs16969968 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of AA, AG, GG. The order of the two letters carries no meaning, so AG and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Nicotine Dependence Risk
Addiction and Substance Response · Part of the Health & Wellness analysis
Encodes a receptor for nicotine, impacting addiction risk and nicotine dependence.
| Genotype | Association |
|---|---|
| AA | Higher Risk |
| AG | Moderate Risk |
| GG | Lower Risk |
- Summary
- Variations in CHRNA5 gene are associated with nicotine addiction susceptibility.
- Scientific insights
- 'AA' alleles are linked to an increased likelihood of nicotine dependence.
- Lifestyle tips
- Behavioral interventions can help in managing dependence risk.
Check your genotype at rs16969968
Load your raw DNA file and Genespiral looks up rs16969968 along with every other marker in the Health & Wellness analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Nicotine Dependence Risk in your results.
Related
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs16969968 - NCBI
- rs16969968 variant page - Ensembl
- rs16969968 summary - SNPedia
- Clinical significance records for rs16969968 - ClinVar
- CHRNA5 gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.