rs12740374
SORT1 (1p13)rs12740374 is a single-nucleotide polymorphism (SNP) in the SORT1 (1p13) gene. Genespiral reads it in the Health & Wellness analysis to describe LDL Cholesterol Levels.
- Gene
- SORT1 (1p13)
- Alleles
- G / T
- Genotypes
- GG, GT, TT
- Traits
- 1 trait across 1 analysis
An rsID such as rs12740374 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of GG, GT, TT. The order of the two letters carries no meaning, so GT and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
LDL Cholesterol Levels
Cardiovascular Health · Part of the Health & Wellness analysis
A variant at the 1p13/SORT1 locus that alters liver SORT1 expression — one of the strongest common influences on LDL ("bad") cholesterol and heart disease risk.
| Genotype | Association |
|---|---|
| GG | Higher LDL tendency |
| GT | Intermediate |
| TT | Lower LDL tendency |
- Summary
- The SORT1 locus is a well-replicated common determinant of LDL cholesterol levels.
- Scientific insights
- The 'T' allele is associated with lower LDL cholesterol and reduced heart disease risk, so 'TT' tends toward lower LDL and 'GG' toward higher.
- Lifestyle tips
- Diet, activity, and (where indicated) medication influence LDL far more than any single variant — a lipid panel is the real measure.
Check your genotype at rs12740374
Load your raw DNA file and Genespiral looks up rs12740374 along with every other marker in the Health & Wellness analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find LDL Cholesterol Levels in your results.
Related
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs12740374 - NCBI
- rs12740374 variant page - Ensembl
- rs12740374 summary - SNPedia
- Clinical significance records for rs12740374 - ClinVar
- SORT1 (1p13) gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.