rs11209026
IL23Rrs11209026 is a single-nucleotide polymorphism (SNP) in the IL23R gene. Genespiral reads it in the Health & Wellness analysis to describe Inflammatory Bowel Disease Protection (IL23R).
- Gene
- IL23R
- Alleles
- A / G
- Genotypes
- GG, AG, AA
- Traits
- 1 trait across 1 analysis
An rsID such as rs11209026 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of GG, AG, AA. The order of the two letters carries no meaning, so AG and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Inflammatory Bowel Disease Protection (IL23R)
Autoimmune and Inflammatory Conditions · Part of the Health & Wellness analysis
The IL23R Arg381Gln variant dampens interleukin-23 immune signalling; the Gln (A) allele is protective against Crohn’s disease, ulcerative colitis, psoriasis, and ankylosing spondylitis.
| Genotype | Association |
|---|---|
| GG | Typical risk |
| AG | Reduced risk (protective allele) |
| AA | Strongly reduced risk |
- Summary
- The rarer IL23R protective allele lowers the risk of several inflammatory conditions, notably inflammatory bowel disease.
- Scientific insights
- Carriers of the 'A' (Gln381) allele have reduced risk of inflammatory bowel disease and related conditions; 'GG' is the common, typical-risk genotype.
- Lifestyle tips
- This variant lowers risk but does not eliminate it; report persistent gut symptoms to a clinician.
Check your genotype at rs11209026
Load your raw DNA file and Genespiral looks up rs11209026 along with every other marker in the Health & Wellness analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Inflammatory Bowel Disease Protection (IL23R) in your results.
Related
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs11209026 - NCBI
- rs11209026 variant page - Ensembl
- rs11209026 summary - SNPedia
- Clinical significance records for rs11209026 - ClinVar
- IL23R gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.