rs10484554
LCE3B/LCE3Crs10484554 is a single-nucleotide polymorphism (SNP) in the LCE3B/LCE3C gene. Genespiral reads it in the Health & Wellness analysis to describe Psoriasis Risk.
- Gene
- LCE3B/LCE3C
- Alleles
- C / T
- Genotypes
- TT, TC, CC
- Traits
- 1 trait across 1 analysis
An rsID such as rs10484554 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of TT, TC, CC. The order of the two letters carries no meaning, so TC and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Psoriasis Risk
Skin and Hair Conditions · Part of the Health & Wellness analysis
Involved in skin barrier function, impacting susceptibility to inflammatory skin conditions.
| Genotype | Association |
|---|---|
| TT | Increased Risk |
| TC | Moderate Risk |
| CC | Lower Risk |
- Summary
- LCE3B/LCE3C gene variations are linked to an increased risk of psoriasis.
- Scientific insights
- 'TT' genotype individuals have a higher likelihood of psoriasis, especially with family history.
- Lifestyle tips
- Moisturizing regularly and avoiding skin irritants may help manage symptoms.
Check your genotype at rs10484554
Load your raw DNA file and Genespiral looks up rs10484554 along with every other marker in the Health & Wellness analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Psoriasis Risk in your results.
Related
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs10484554 - NCBI
- rs10484554 variant page - Ensembl
- rs10484554 summary - SNPedia
- Clinical significance records for rs10484554 - ClinVar
- LCE3B/LCE3C gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.