rs1805008
MC1Rrs1805008 is a single-nucleotide polymorphism (SNP) in the MC1R gene. Genespiral reads it in the Appearance analysis to describe Freckles.
- Gene
- MC1R
- Alleles
- C / T
- Genotypes
- CC, CT, TT
- Traits
- 1 trait across 1 analysis
An rsID such as rs1805008 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of CC, CT, TT. The order of the two letters carries no meaning, so CT and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Freckles
Appearance · Part of the Appearance analysis
Associated with red hair and skin pigmentation, influencing freckle formation.
| Genotype | Association |
|---|---|
| CC | No Freckles |
| CT | Freckles |
| TT | Freckles |
- Summary
- MC1R gene variations can increase susceptibility to freckles, especially with sun exposure.
- Scientific insights
- 'TT' genotype has a strong association with freckle formation, particularly in fair-skinned individuals.
- Lifestyle tips
- Regular sunscreen use can help prevent sun-related skin changes, including freckling.
Check your genotype at rs1805008
Load your raw DNA file and Genespiral looks up rs1805008 along with every other marker in the Appearance analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Freckles in your results.
Related
Other markers in MC1R
More markers from Appearance
Articles that discuss rs1805008
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs1805008 - NCBI
- rs1805008 variant page - Ensembl
- rs1805008 summary - SNPedia
- Clinical significance records for rs1805008 - ClinVar
- MC1R gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.