rs1154155
HLA-DQB1rs1154155 is a single-nucleotide polymorphism (SNP) in the HLA-DQB1 gene. Genespiral reads it in the Sleep analysis to describe Narcolepsy Risk.
- Gene
- HLA-DQB1
- Alleles
- A / G
- Genotypes
- AA, AG, GG
- Traits
- 1 trait across 1 analysis
An rsID such as rs1154155 is the reference number dbSNP assigns to one position in the genome where people commonly differ by a single letter. Raw data exports from 23andMe and AncestryDNA list your two alleles at that position as a genotype - for this marker one of AA, AG, GG. The order of the two letters carries no meaning, so AG and its reverse are the same genotype.
Alleles on this page are written on the forward (plus) strand, matching how consumer raw files report them. Other references sometimes describe the same variant on the opposite strand, which swaps A↔T and C↔G - see why the same variant can look different. The associations below are educational summaries of published research; they are not diagnoses, and the effect of any single SNP is usually modest.
Narcolepsy Risk
Sleep Disorders · Part of the Sleep analysis
Involved in immune response, associated with narcolepsy risk.
| Genotype | Association |
|---|---|
| AA | Higher risk of narcolepsy |
| AG | Moderate risk |
| GG | Lower risk |
- Summary
- Variations in HLA-DQB1 are linked to an increased likelihood of narcolepsy.
- Scientific insights
- 'AA' genotype individuals have a higher likelihood of developing narcolepsy.
- Lifestyle tips
- Maintaining regular sleep schedules can help manage narcoleptic symptoms.
Check your genotype at rs1154155
Load your raw DNA file and Genespiral looks up rs1154155 along with every other marker in the Sleep analysis. The file is parsed in your browser and never uploaded, so your genotype stays on your device.
- 1. Download your raw data from 23andMe or AncestryDNA.
- 2. Open the analysis below and choose the file.
- 3. Find Narcolepsy Risk in your results.
Related
Other markers in HLA-DQB1
References
Primary databases for this variant. Use them to check allele orientation, population frequencies, and the underlying studies.
- dbSNP entry for rs1154155 - NCBI
- rs1154155 variant page - Ensembl
- rs1154155 summary - SNPedia
- Clinical significance records for rs1154155 - ClinVar
- HLA-DQB1 gene - NCBI Gene
Genespiral is an educational tool, not a medical service. Genetic associations describe tendencies observed across populations, not certainties for you. Read the full disclaimer.